TABLE 2.

Hepatic ¹⁸F-FDGal Kinetics in Absence of Galactose

Subject no.	${\mathrm{V}}_{\text{max}}^{*}/{\mathrm{K}}_{\mathrm{m}}^{*}$ (L blood/min)	${\mathrm{V}}_{\text{max}}^{*}/(\mathrm{F}{\mathrm{K}}_{\mathrm{m}}^{*})$	Approximation of ${\mathrm{K}}_{\text{syst}}^{*}\text{to}{\mathrm{V}}_{\text{max}}^{*}/{\mathrm{K}}_{\mathrm{m}}^{*}$	${\mathrm{K}}_{-\text{gal}}^{*}$ (L blood/min/L liver tissue)
1	0.41 ± 0.07	0.35 ± 0.06	85%	0.265 ± 0.003
2	0.33 ± 0.03	0.36 ± 0.04	84%	0.213 ± 0.006
3	0.50 ± 0.09	0.29 ± 0.06	87%	0.279 ± 0.004
4	ND	ND	ND	0.229 ± 0.008
5	0.52 ± 0.09	0.39 ± 0.07	83%	0.342 ± 0.004
6	0.33 ± 0.04	0.35 ± 0.05	84%	0.253 ± 0.004
7	0.24 ± 0.06	0.27 ± 0.06	88%	0.273 ± 0.002
8	0.32 ± 0.06	0.29 ± 0.06	87%	0.295 ± 0.008
Mean ± SE	0.38 ± 0.02	0.33 ± 0.02	85%	0.274 ± 0.001

${\mathrm{V}}_{\text{max}}^{*}/{\mathrm{K}}_{\mathrm{m}}^{*}$ = intrinsic clearance of ¹⁸F-FDGal; F = hepatic blood flow (L blood/min; Table 1); ${\mathrm{K}}_{\text{syst}}^{*}$ = hepatic systemic clearance of ¹⁸F-FDGal; ${\mathrm{K}}_{-\text{gal}}^{*}$ = hepatic systemic clearance of ¹⁸F-FDGal calculated from PET study without galactose infusion; ND = not determined (in subject 4, no liver vein blood samples were obtained during PET study); mean ± SE = weighted mean ± SE of the weighted mean.

Individual values are given as estimate ± SE of estimate.