Table 3.
List of proteins most frequently targeted by more than two viruses. Column 1: Protein name. Column 2: Uniprot id of the protein. Column 3: Indicates (yes/no) whether the protein is listed as drug target in DrugBank. Column 4: Number of pathways in which the protein participates. Column 5: Number of viruses that interact with the protein. Column 6: List of the viruses targeting the protein via PPI
| Protein name | UniProt ID |
Drug target |
Pathways | Virus target |
Viruses |
|---|---|---|---|---|---|
| Histone acetyltransferase p300 | Q09472 | No | 15 | 6 | HIV,HAdV,SV,MPyV,HPV,BPV |
| Cell division control protein 2 homologue | P06493 | Yes | 18 | 5 | HAdV,HIV,EBV,HPV,SV |
| Serine/threonine-protein phosphatase 2A | P67775 | Yes | 1 | 5 | RSV,SV,MPyV,HIV,HPV |
| CREB-binding protein | Q92793 | No | 16 | 5 | HAdV,SV,HIV,MPyV,HPV |
| TATA-box-binding protein | P20226 | No | 12 | 5 | HAdV,SV,HIV,HPV,BPV |
| Transcription initiation factor IIB | Q00403 | No | 8 | 5 | HHV,HIV,SV,BPV,HPV |
| Transcription initiation factor TFIID | P21675 | No | 8 | 5 | SV,HIV,HAdV,BPV,HPV |
| Cellular tumour antigen p53 | P04637 | No | 7 | 5 | HAdV,HCV,HPV,SV,HIV |
| GTP-binding nuclear protein Ran | P62826 | Yes | 12 | 4 | HAdV,HIV,HPV,SV |
| Histone deacetylase 1 | Q13547 | Yes | 10 | 4 | HAdV,SV,FAdV,HPV |
| Casein kinase II subunit alpha | P68400 | Yes | 7 | 4 | SV,HPV,HIV,EBV |
| Retinoblastoma-associated protein | P06400 | Yes | 4 | 4 | HPV,HAdV,SV,MAV |
| Importin subunit alpha-2 | P52292 | No | 2 | 4 | EBV,HIV,SV,HPV |
| Transcription factor AP-1 | P05412 | Yes | 23 | 3 | VACV/VV,HIV,HPV |
| RAF serine/threonine-protein kinase | P04049 | Yes | 18 | 3 | ASV,HIV,HCV |
| Cell division protein kinase 2 | P24941 | Yes | 17 | 3 | SV,HIV,HPV |
| DNA polymerase catalytic subunit | P09884 | Yes | 8 | 3 | SV,HPV,HHV |
| Histone acetyltransferase PCAF | Q92831 | Yes | 6 | 3 | HAdV,HIV,HPV |
| Tyrosine-protein kinase LCK | P06239 | No | 44 | 3 | SaHV,HCV,HIV |
| Transcription factor Sp1 | P08047 | No | 8 | 3 | HHV,HIV,SV |
| Transcription initiation factor TFIID | P49848 | No | 8 | 3 | HIV,BPV,HPV |
| CCAAT/enhancer-binding protein | P17676 | No | 7 | 3 | HIV,HPV,BPV |
| Importin subunit beta-1 | Q14974 | No | 5 | 3 | HIV,SV,HPV |
| ATP-dependent DNA helicase 2 | P13010 | No | 4 | 3 | HIV,EBV,HHV |
| DNA-dependent protein kinase | P78527 | No | 4 | 3 | HAdV,HIV,HHV |
| Guanine nucleotide-binding protein | P63244 | No | 4 | 3 | EBV,HAdV,HIV |
| Nucleophosmin | P06748 | No | 3 | 3 | HDV,HAdV,HIV |
| Small ubiquitin-related modifier 1 | P63165 | No | 3 | 3 | SARS-CoV,BPV,HPV |
| E3 ubiquitin-protein ligase | Q96J02 | No | 2 | 3 | CeHV,EBV,HIV |
| E3 ubiquitin-protein ligase NEDD4 | P46934 | No | 2 | 3 | RSV,EBOV,HIV |
| Bcl-2 homologous antagonist/killer | Q16611 | No | 1 | 3 | HAdV,VACV/VV,HPV |
| Double-stranded RNA-activated protein kinase | P19525 | No | 1 | 3 | VACV/VV,HCV,HIV |
| Retinoblastoma-like protein 2 | Q08999 | No | 1 | 3 | HIV,HAdV,HPV |
| Tyrosine-protein kinase HCK | P08631 | Yes | 39 | 2 | HIV,HCV |
| Phosphatidylinositol 3-kinase | P27986 | Yes | 38 | 2 | FLUAV,HIV |
| Mitogen-activated protein kinase 1 | P28482 | Yes | 35 | 2 | HHV,HIV |
| Ubiquitin | P62988 | Yes | 27 | 2 | HIV,EBV |
| Signal transducer, activator of transcription 1-alpha/beta | P42224 | Yes | 18 | 2 | HAdV,HCV |
| DNA replication licensing factor MCM7 | P33993 | Yes | 10 | 2 | FLUAV,HPV |
| Histone deacetylase 2 | Q92769 | Yes | 10 | 2 | HHV,HPV |
| Heat shock cognate 71 kDa protein | P11142 | Yes | 4 | 2 | FLUAV,EBV |
| D-isomer specific 2-hydroxyacid dehydrogenase | Q13363 | Yes | 3 | 2 | EBV,HAdV |
| Poly [ADP-ribose] polymerase 1 | P09874 | Yes | 2 | 2 | HHV,SV |
| Tubulin alpha-1B chain | P68363 | Yes | 2 | 2 | HIV,EBV |
| CAD protein | P27708 | Yes | 1 | 2 | HAdV,EBV |