Table 1.
Paraneoplastic cerebellar degeneration
| Date | Fluid |
Antibodies |
Proteins | Findings | |
|---|---|---|---|---|---|
| Anti-Yo | Anti-GAD | ||||
| 1 August 2008 |
Serum |
2U (range 0 to 3) |
4.3U/mL (<1) |
|
Anti-Yo confirmed on immunoblot |
| CSF |
1U |
2.0U/mL |
14-3-3 |
|
|
| Serum:CSF ratio = 2:1 |
Serum:CSF ratio = 2.15:1 |
|
|
||
| 5 August 2008 |
|
Intravenous Ig 28 g (0.4 g/kg per day for five days) |
|
|
|
| 1 September 2008 |
|
Laparotomy, hysterectomy, bilateral salpingoophorectomy |
|
|
|
| 9 April 2009 |
Serum |
1U |
0.2U/mL |
|
|
| |
CSF |
Undetectable |
Undetectable |
|
|
| 23 December 2009 |
Serum |
0 |
<0.1U/mL |
|
|
| 24 December 2010 |
Serum |
0 |
<0.1U/mL |
|
|
| 7 November 2011 | Patient alive; Rankin score 5 | ||||
Anti-Yo antibodies detected by indirect immunofluorescence on a composite block of primate cerebellum and cerebrum, and mouse stomach (titers expressed 0 = not detected; 1 = weak positive; 2 = moderate positive; 3 = strong positive). GAD antibodies (GAD 65) are measured using a radioimmunoassay and expressed in U/mL (reference range <1).
CSF, cerebrospinal fluid; GAD, glutamic acid decarboxylase.