Table 4.
Multivariate Cox proportional hazards analysis of overall survival in colorectal adenocarcinoma
| Variables | HR (95% CI) | P-value | |
|---|---|---|---|
| Gender |
|
|
0.020 |
| |
Female |
1.0 |
|
| |
Male |
1.278 (1.040, 1.572) |
|
| Age, years |
|
|
0.007 |
| |
< 65 |
1.0 |
|
| |
≧ 65 |
1.317 (1.078, 1.608) |
|
| Location |
|
|
0.020 |
| |
Colon |
1.0 |
|
| |
Rectum |
1.267 (1.038, 1.547) |
|
| Size, cm |
|
|
0.112 |
| |
< 5 |
1.0 |
|
| |
≧ 5 |
1.184 (0.961, 1.459) |
|
| Preoperative serum CEA, ng/ml |
|
< 0.001 |
|
| |
< 5.0 |
1.0 |
|
| |
≧ 5.0 |
1.483 (1.203, 1.828) |
|
| Depth of invasiona |
|
< 0.001 |
|
| |
T1, T2 |
1.0 |
|
| |
T3, T4 |
2.253 (1.534, 3.308) |
|
| Lymph node metastasisa |
|
< 0.001 |
|
| |
N0 |
1.0 |
|
| |
N1, N2 |
2.427 (1.893, 3.105) |
|
| Distant metastasisa |
|
< 0.001 |
|
| |
M0 |
1.0 |
|
| |
M1 |
4.165 (3.350, 5.179) |
|
| Operating facility |
|
0.032 |
|
| |
Center A |
1.0 |
|
| |
Center B |
1.192 (1.002, 1.395) |
|
| Histological type |
|
< 0.001 |
|
| |
NMA |
1.0 |
|
| MA | 2.226 (1.618, 3.062) | ||
aStaging of tumor (T), nodes (N), and metastases (M) [24]; HR, hazard ratio; CI, confidence interval; NMA, non-mucinous adenocarcinoma; MA, mucinous adenocarcinoma.