Table 2.
Demographic, laboratory and clinical summary of HIV-2 infected children on antiretroviral therapy
| Patient | Sex | Age at diagnosis (years) | Parents status | Age at start of ART (years) | Baseline CD4+count (%CD4) | Baseline Viral load (log10copies/ml) | Remarks |
|---|---|---|---|---|---|---|---|
| 1 |
F |
11 |
Both parents alive; HIV status unknown |
12 |
40 (1%) |
Nil |
WHO stage 4 at start of ART Clinical follow-up for 2 months No follow-up laboratory data; Died |
| 2 |
M |
8 |
Mother dead (HIV-2 positive), Father alive (HIV-negative) |
14 |
280 (27%) |
4.5 |
WHO stage 4 at start of ART Clinical follow-up for 38 months Sub-optimal CD4 recovery; >0.5 log10 increase in viral load at 12 weeks; did not achieve virologic suppression throughout follow-up; LTFU |
| 4 |
F |
2 |
Both parents HIV-2 positive and alive (both on ART) |
4 |
570 (13%) |
4.6 |
WHO stage 3 at start of ART Clinical follow-up for 10 months No CD4 cell gain; ART discontinued at 29 weeks due to poor adherence; No follow-up viral load data; LTFU |
| 5 |
M |
6 |
Mother dead, father unknown; both parents HIV status unknown |
6 |
140 (4%) |
3.1 |
WHO stage 3 at start of ART Clinical follow-up for 4 months No follow-up laboratory data; Died |
| 6 | M | 12 | Mother dead, father unknown; both parents HIV status unknown | 12 | 110 (8%) | 4.9 | WHO stage 2 at start of ART Clinical follow-up for 3 months Achieved an increase in CD4 count of 50 cells/mm3 but a 1.0 log10 increase in viral load at 12 weeks; LTFU |
NOTE. LTFU = Lost to follow-up; EPTB = Extra pulmonary tuberculosis; PTB = Pulmonary tuberculosis.