Table 1.
Sensitivity and specificity of the AS-PCR and AS-LAMP methods forkdrmutation detection
| Genotype* |
Detection Method |
|
Sensitivity (95% CL) |
|
Specificity (95% CL) |
|
|
|---|---|---|---|---|---|---|---|
| Sequencing | AS-PCR | AS-LAMP | AS-PCR | AS-LAMP | AS-PCR | AS-LAMP | |
|
kdr-w/kdr-w |
20 |
20 |
23 |
0.83 (0.64 - 0.93) |
0.92 (0.74 - 0.98) |
1 (0.96 - 1) |
0.99 (0.94 - 1) |
|
kdr-w/+ |
26 |
18 |
20 |
0.94 (0.73 - 0.99) |
0.94 (0.73 - 0.99) |
0.98 (0.92 - 0.98) |
0.96 (0.90 - 0.98) |
|
+/+ |
70 |
73 |
70 |
0.93 (0.85 - 0.97) |
0.99 (0.92 - 1) |
0.94 (0.83 - 0.98) |
1 (0.92 - 1) |
| Unidentified |
4 |
9 |
7 |
- |
- |
- |
- |
| Total | 120 | 120 | 120 | - | |||
Genotypes were analysed by sequencing, AS-LAMP, and AS-PCR. The sensitivity and specificity of the AS-PCR and AS-LAMP methods relative to sequencing are expressed as proportions, and their 9~~confidence limits (CL) are shown in parenthesis.