Table 3.
Cumulative biodistribution data of [111In]AT2S in AR4-2J and HEK293-hsst2A+, -hsst3+, and -hsst5+tumor-bearing SCID mice
| [111In]AT2S (%ID/g tissue ± SD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Organs |
AR4-2J |
HEK293-hsst2A+ |
HEK293-hsst3+ |
HEK293-hsst5+ |
|||||
| |
1 h |
4 h |
4 h + Tatea |
4 h |
4 h + DP2b |
4 h |
4 h + AT2Sc |
4 h |
4 h + AT2Sc |
| Blood |
1.34 ± 0.21 |
0.19 ± 0.02 |
0.26 ± 0.03 |
0.23 ± 0.07 |
0.66 ± 0.35 |
0.19 ± 0.03 |
0.2 ± 0.10 |
0.1 ± 0.04 |
0.23 ± 0.03 |
| Liver |
1.27 ± 0.09 |
0.95 ± 0.21 |
1.02 ± 0.11 |
1.31 ± 0.36 |
0.963 ± 0.67 |
1.02 ± 0.19 |
1.09 ± 0.2 |
1.1 ± 0.08 |
1.25 ± 0.09 |
| Heart |
0.67 ± 0.12 |
0.18 ± 0.05 |
0.17 ± 0.04 |
0.22 ± 0.05 |
0.38 ± 0.10 |
0.15 ± 0.04 |
0.15 ± 0.01 |
0.15 ± 0.02 |
0.18 ± 0.03 |
| Kidneys |
23.83 ± 4.28 |
21.10 ± 4.43 |
24.41 ± 9.15 |
23.20 ± 7.04 |
25.51 ± 3.70 |
23.42 ± 4.69 |
23.55 ± 8.96 |
24.12 ± 1.21 |
24.68 ± 2.20 |
| Stomach |
3.23 ± 0.77 |
1.81 ± 0.47 |
0.18 ± 0.07*** |
1.96 ± 0.53 |
1.29 ± 0.36 |
3.41 ± 0.97 |
0.19 ± 0.05*** |
3.06 ± 0.73 |
0.17 ± 0.2*** |
| Intestines |
1.98 ± 0.29 |
1.92 ± 0.25 |
0.77 ± 0.58* |
2.00 ± 0.48 |
1.74 ± 1.02 |
2.39 ± 0.43 |
0.54 ± 0.2*** |
1.54 ± 0.09 |
0.57 ± 0.20*** |
| Spleen |
0.84 ± 0.21 |
1.10 ± 0.63 |
0.61 ± 0.18 |
0.46 ± 0.11 |
0.50 ± 0.36 |
0.82 ± 0.11 |
0.98 ± 0.23 |
0.78 ± 0.07 |
1.08 ± 0.16 |
| Muscle |
0.22 ± 0.02 |
0.06 ± 0.01 |
0.07 ± 0.01 |
0.07 ± 0.02 |
0.07 ± 0.03 |
0.06 ± 0.01 |
0.07 ± 0.02 |
0.06 ± 0.01 |
0.06 ± 0.02 |
| Lung |
2.05 ± 0.52 |
1.43 ± 1.36 |
3.30 ± 4.93 |
1.37 ± 0.55 |
0.47 ± 0.08 |
0.68 ± 0.29 |
0.73 ± 0.14 |
0.56 ± 0.28 |
0.83 ± 0.13 |
| Femur |
0.49 ± 0.12 |
0.40 ± 0.24 |
0.19 ± 0.02 |
0.24 ± 0.09 |
0.21 ± 0.11 |
0.23 ± 0.03 |
0.23 ± 0.04 |
- |
- |
| Pancreas |
7.35 ± 0.74 |
5.13 ± 0.75 |
0.15 ± 0.05** |
5.73 ± 1.28 |
0.16 ± 0.10*** |
3.33 ± 0.4 |
0.11 ± 0.01*** |
2.79 ± 0.4 |
0.43 ± 0.54*** |
| Tumor | 3.05 ± 0.51 | 1.82 ± 0.36 | 0.21 ± 0.17*** | 1.49 ± 0.2 | 0.27 ± 0.20*** | 1.24 ± 0.27 | 0.32 ± 0.06*** | 0.41 ± 0.12 | 0.22 ± 0.006* |
*Significant (p < 0.05), and ** and ***highly significant (p < 0.005) difference between blocked and unblocked animals (Student’s t test). aCo-injection of 50 nmol Tate; bco-injection of 35 nmol DP2; cco-injection of 35 nmol AT2S.