Table 3. Palladium-catalyzed [3+2] reactions of N-Boc imines^a.

entry	substrate	product	temp (°C)	% yield	% ee
1			45	98	87
			4	84	91
2			4	80	92
3			4	83	86
			−15	73	90
4			4	94	93
5			4	91	90
6			4	96	91
7			4	93	85
			−15	94	86
8			4	73	84
9			4	86	84
10b			4	86	85
11			4	71	88
			−15	65	90
12			4	81	83
13			4	75	86
14			4	71	91
15			4	74	88
			−15	60	90
16			4	74	70
17			4	88	72
18			4	43	22

^aAll reactions were performed at 0.2 M in toluene with 5 mol% Pd(dba)₂, 10 mol% ligand, 1.6 equiv 1, and stirred for 4 hours. Yields are isolated values; ee's were determined by chiral HPLC or chiral GC.

^bReaction performed with 2.5 mol% Pd(dba)₂ and 5 mol% L12.