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Characteristics of secondary leukemia following epipodophyllotoxin or alkylating agent treatment.
| Epipodophyllotoxin | Alkylating agent | |
|---|---|---|
| Typical interval following therapy | 2–3 years | 5–7 years |
| FAB classification | M4/M5 | M1/M2 |
| Karyotype abnormalities | 11q3 (MLL gene rearrangement) | (–5)/del(5q), (–7)/del(7q) |
| Preceding myelodysplasia | rare | frequent |
