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Comparison of the activity of wild-type APETx2 with cyclic and truncation analogues. Concentration-effect curves are shown for inhibition of rASIC3 currents by APETx2 wt (black), APETx2_1–39 (red) and APETx2_3–42 (cyan) (n = 6). The activity of the cyclic APETx2 analogues is shown only at 1 µM (n = 6).
