Figure 2.

Immunocytochemistry for TH in the ventral midbrain of adult WT (A) and DA-βcat KO mice (B). To determine the effect of β-catenin ablation in DA neurons, we compared the number of TH-positive cells and regional organization of the ventral midbrain region of adult animals. No differences were found in the morphological appearance of the ventral midbrain in adult WT and KO animals. (C) The mean number of TH-positive profiles was similar in DA-βcat KO and WT animals. (D) The size of DA neurons in the substantia nigra compacta (SNC) and ventral tegmental area (VTA) did not change in KO mice when compared to WT animals. Student's t-test; P > 0.05.