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. 2012 Mar 21;4(7):594–602. doi: 10.1002/emmm.201200233

Figure 3. Oncogenic K-RAS induced PML protein upregulation depends on MEK1 and TSC2.

Figure 3

  1. WB of Tet-o-K-Ras/p53−/−/rtTA MEFs treated with dox and rapamycin as indicated.
  2. WB of p53 null MEFs transduced and treated with U0126 as indicated.
  3. WB of p53 null MEFs transduced with the indicated retroviruses.
  4. WB analysis of p53 null MEFs transduced as indicated.
  5. WB of p53 null MEFs following retroviral transduction.
  6. WB analysis of tet-o-K-Ras/p53−/−/rtTA following siRNA transfection and dox treatment. The intensity of the bands is expressed with the indicated ratios.