Table 2.

Estimated annual change in IE hospitalizations

	Before Guidelines	p-value*	After Guidelines	Difference	p-value**
Number of IE cases
Overall	+1.4% (−2.9%, +5.8%)	0.54	+3.0% (−1.9%, +8.1%)	+1.6% (−6.4%, +10.3%)	0.70
CHD patients only	−5.3% (−17.4%, +8.5%)	0.43	−11.8% (−24.0%, +2.4%)	−6.8% (−27.7%, +20.1%)	0.58
Age 5–18 y only	+1.8% (−5.9%, +10.1%)	0.66	+1.4% (−7.3%, +10.8%)	−0.4% (−14.2%, +15.7%)	0.96
Oral streptococcal only	−2.5% (−14.2%, +10.9%)	0.70	−19.1% −32.4%, −3.1%)	−17.1% (−36.9%, +9.0%)	0.18
Number of IE cases/ 1000 hospital admissions
Overall	−5.9% (−9.9%, −1.8%)	0.005	−11.5% (−15.7%, −7.1%)	−5.9% (−13.3%, +2.2%)	0.15
CHD patients only	−12.3% (−24.9%, +2.5%)	0.10	−23.5% (−35.2%, −9.6%)	−12.8% (−34.5%, +16.2%)	0.35
Age 5–18y only	−5.5% (−12.6%, +2.2%)	0.15	−12.9% (−20.4%, −4.7%)	−7.8% (−20.7%, +7.2%)	0.29
Oral streptococcal only	−9.2% (−20.2%, +3.2%)	0.14	−30.9% (−42.3%, −17.1%)	−23.9% (−42.1%, +0.1%)	0.05

Data are presented as estimated annual change in cases of IE and 95% confidence intervals. The data in the “Difference” column show the difference in the post- vs. pre-guidelines period

^*p-value for estimated annual change before guidelines.

^**p-value for estimated difference in the post- vs. pre-guidelines period; represents whether the estimated annual change differs significantly between time periods.

CHD=congenital heart disease