Figure 2. Dose reduction analysis of safingol (Saf)-based drug combinations. The drug concentrations required to achieve 90% cell-kill for safingol (white bars) and respective anti-cancer drugs (black bars) used alone or in 1:4 and 4:1 fixed molar ratios are shown. (A-D) Carb, carboplatin; Dox, doxorubicin; Gem, gemcitabine; and Vinc, vincristine.