Figure 3. Apoptosis assays of tumor tissues in different groups. (A-E) TUNEL staining of tumors revealed that combination therapy induced a significant enhancement of apoptotic cells in contrast to control therapies; magnification, x400. Apoptosis index of LH plus DDP-treated tumor was elevated compared to that of (F) the control groups. Values are the means ± SD. LH, liposomal honokiol; DDP, cisplatin; NS, normal saline and EL, empty liposomes.