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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Biochem Pharmacol. 2012 Mar 3;83(10):1445–1455. doi: 10.1016/j.bcp.2012.02.021

Figure 1.

Figure 1

Activation of GAL4-Nurr1 chimeras by C-DIMs. UASx5-Luc (400 ng) and GAL4-Nurr1 (40 ng) were cotransfected into Panc28 (A, B) and Panc1 (C, D) cells for 6 hr and then treated with 7.5 and 15 μM phenyl-substituted C-DIMs including trifluoromethyl (CF3), bromo (Br), fluoro (F), tert-butyl (t-Bu), dimethylamino (N(CH3)2), hydrogen (H), hydroxy (OH), phenyl (C6H5), cyano (CN), methyl (CH3), chloro (Cl), iodo (I), carboxymethyl (CO2Me) (A, C), methoxy (OCH3), tert-butoxy (OBu) or trifluoromethoxy (OCF3) (B, D) group on the para position, or the heterocyclic C-DIMs including 2-furan, 3-thiophene, 3-pyrrole, piperonal, 4-pyridine, 4-pyridine-N-oxide or indole ring (B, D) for 18 hr. Luciferase activity was determined as described in the Materials and Methods. Results are expressed as means ± SD for at least three separate determinations for each treatment. *, P < 0.05, high concentration treatment (15 μM) vs. solvent control (DMSO).