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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Biochem Pharmacol. 2012 Mar 3;83(10):1445–1455. doi: 10.1016/j.bcp.2012.02.021

Figure 3.

Figure 3

Selected NR4A2 activators increase activities of Nur response elements containing NBREx3-Luc and NurREx3-Luc luciferase genes. NBREx3-Luc (200 ng) (A, C) or NurREx3-Luc (200 ng) (B, D) was cotransfected with FLAG-Nurr1 (10 ng) into Panc28 (A, B) or Panc1 (C, D) cells for 6 hr and then treated with 7.5 and 15 μM p-substituted phenyl-C-DIMs DIM-C-pPhI, -pPhBr, -pPhCF3, and -pPhOCF3 for 18 hr. Luciferase activity was determined as described in the Materials and Methods. Results are expressed as means ± SD for at least three separate determinations for each treatment. *, P < 0.05, high concentration treatment (15 μM) vs. solvent control (DMSO).