Table 3.
BP measurements before and after 8 weeks of maximally tolerated carvedilol among 25 participants with intradialytic hypertension
| Baseline (n=25) | Study End (n=25) | Mean Change from Baseline to Study end | P Value | |
|---|---|---|---|---|
| 2-wk frequency of intradialytic hypertension (%) | 77% (4.6 of 6 sessions) | 28% (1.7 of 6 sessions) | 49% (2.9 of 6 sessions) | <0.001 |
| 2-wk average BP (mmHg)a | ||||
| predialysis systolic | 144.0 (±9.7) | 146.1 (±14.4) | 2.2 (±16.9) | 0.5 |
| postdialysis systolic | 159.0 (±9.3) | 142.4 (±12.7) | −16.7 (±16.7) | <0.001 |
| predialysis diastolic | 77.5 (±9.2) | 75.9 (±8.9) | −1.6 (±9.6) | 0.4 |
| postdialysis diastolic | 80.9 (±7.6) | 72.5 (±23.9) | −8.4 (±22.8) | 0.08 |
| Δ systolic (postdialysis–predialysis) | +15.0 (±9.1) | −3.8 (±16.1) | −18.8 (±16.5) | <0.001 |
| Ambulatory BP (mmHg) | ||||
| systolic (44-hr) | 155.4 (±14.2) | 147.7 (±16.2) | −7.5 (±16.8) | 0.04 |
| daytime systolic | 155.7 (±14.9) | 146.9 (±15.9) | −8.2 (±18.5) | 0.04 |
| nighttime systolic | 155.6 (±16.4) | 149.8 (±19.7) | −4.1 (±18.2) | 0.3 |
| diastolic (44-hr) | 82.4 (±10.8) | 77.7 (±9.7) | −4.2 (±7.7) | 0.01 |
| daytime diastolic | 83.2 (±11.8) | 77.6 (±9.7) | −4.7 (±8.8) | 0.02 |
| nighttime diastolic | 80.9 (±10.6) | 77.0 (±11.1) | −2.8 (±7.3) | 0.09 |
| Central aortic BP (mmHg) | ||||
| systolic | 153.7 (±30.8) | 147.3 (±34.8) | −6.4 (±25.7) | 0.2 |
| diastolic | 76.1 (±11.5) | 75.6 (±12.4) | −0.5 (±10.2) | 0.8 |
Values are reported as mean ± SD or n (%). P values determined from paired t tests
a
Values are 2-week averages of BP from the six hemodialysis sessions before intervention and the six hemodialysis sessions at study end.