TABLE 3.
Expressed nAChR | Acetylcholine |
Cytisine |
Nicotine |
Mecamylamine |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Log EC50 | nH ± S.E. | n | Log EC50 | nH ± S.E. | n | Log EC50 | nH ± S.E. | n | Log IC50 | nH ± S.E. | |
α3β4 (1:1) | 6 | −4.2 ± 0.02 | 1.3 ± 0.07 | 6 | −4.7 ± 0.03 | 1.3 ± 0.13 | 6 | −4.7 ± 0.04 | 1.3 ± 0.14 | 6 | −5.3 ± 0.04 | −1.4 ± 0.18 |
α3β4 (1:20) | 4 | −4.3 ± 0.02 | 0.96 ± 0.07 | 4 | −5.1 ± 0.05 | 1.1 ± 0.13 | 4 | −4.6 ± 0.05 | 1.3 ± 0.17 | 4 | −6.0 ± 0.03 | −1.2 ± 0.1 |
α3β4 (20:1) | 4 | −3.7 ± 0.01 | 1.8 ± 0.06 | 4 | −4.2 ± 0.03 | 1.5 ± 0.14 | 4 | −4.3 ± 0.04 | 2.2 ± 0.3 | 4 | −6.9 ± 0.1 | −1.2 ± 0.14 |