TABLE 1.
Genes showing significant -fold changes by microarray analysis
| Gene | Symbol | RefSeq accession no. | p value (KO/WT) | -Fold change (KO/WT) |
|---|---|---|---|---|
| Enolase 2, γ neuronal | Eno2 | NM_013509 | 4.32e−05 | −2.24011 |
| Hedgehog-interacting protein-like 2 | Hhipl2 | BC034362 | 0.000242 | −6.52572 |
| Mannoside acetylglucosaminyltransferase 5 | Mgat5 | NM_145128 | 0.00044 | −2.11392 |
| CD14 antigen | Cd14 | NM_009841 | 0.000607 | 2.13547 |
| N-Acetylneuraminate pyruvate lyase | Npl | NM_028749 | 0.000753 | −3.64734 |
| —a | — | 0.000949 | −3.4074 | |
| Glucosaminyl (N-acetyl) transferase 1, core 2 | Gcnt1 | NM_173442 | 0.00149 | −3.37106 |
| — | — | 0.002031 | −2.03624 | |
| Regulator of G-protein signaling 2 | Rgs2 | NM_009061 | 0.003417 | −3.81328 |
| Adenylate kinase 3-like 1 | Ak3l1 | NM_009647 | 0.003423 | −2.26087 |
| RIKEN cDNA 1700040L02 gene | 1700040L02Rik | BC087900 | 0.004049 | 2.81943 |
| Interferon-activated gene 202B | Ifi202b | NM_008327 | 0.005126 | −2.69043 |
| — | — | 0.009093 | 2.03234 | |
| Solute carrier family 38, member 3 | Slc38a3 | NM_023805 | 0.00921 | 2.13304 |
| — | — | 0.009639 | 2.23546 | |
| Heat shock protein 1A | Hspa1a | NM_010479 | 0.010781 | −2.13604 |
| Potassium inwardly rectifying channel, subfamily J, member 13 | Kcnj13 | NM_001110227 | 0.012275 | −2.13735 |
| — | — | 0.01239 | −2.1894 | |
| Dipeptidylpeptidase 10 | Dpp10 | NM_199021 | 0.01564 | −4.71333 |
| RAS guanyl-releasing protein 1 | Rasgrp1 | NM_011246 | 0.015876 | −2.32995 |
| ENSMUSG00000072618 | ENSMUST00000100713 | 0.016753 | 3.72366 | |
| Caspase 12 | Casp12 | NM_009808 | 0.017624 | 2.50816 |
| d-Aspartate oxidase | Ddo | NM_027442 | 0.017712 | 2.01305 |
| Actin-binding LIM protein family, member 3 | Ablim3 | NM_198649 | 0.020009 | −2.25541 |
| Zinc finger protein 521 | Zfp521 | NM_145492 | 0.020746 | 3.12831 |
| Protocadherin β19 | Pcdhb19 | NM_053144 | 0.020934 | 2.02627 |
| NAD(P)H dehydrogenase, quinone 1 | Nqo1 | NM_008706 | 0.020957 | 2.4185 |
| — | — | 0.021262 | 2.29063 | |
| Protocadherin β18 | Pcdhb18 | NM_053143 | 0.021566 | 2.21905 |
| — | — | 0.022472 | 3.79211 | |
| Mohawk homeobox | Mkx | NM_177595 | 0.022573 | −2.66449 |
| V-set domain-containing T cell activation inhibitor 1 | Vtcn1 | NM_178594 | 0.022682 | 2.55331 |
| Scrapie-responsive gene 1 | Scrg1 | NM_009136 | 0.023531 | 3.86718 |
| — | — | 0.02368 | −2.07973 | |
| Major facilitator superfamily domain-containing 4 | Mfsd4 | NM_001114662 | 0.026284 | −3.09621 |
| Secernin 1 | Scrn1 | NM_027268 | 0.026819 | 2.32697 |
| Insulin-like growth factor-binding protein 4 | Igfbp4 | NM_010517 | 0.027816 | −2.30083 |
| SPARC-related modular calcium binding 1 | Smoc1 | NM_001146217 | 0.027821 | 2.88559 |
| Cadherin 19, type 2 | Cdh19 | NM_001081386 | 0.028015 | −3.07028 |
| — | — | 0.028619 | −2.0569 | |
| RIKEN cDNA 1700055N04 gene | 1700055N04Rik | AK081788 | 0.03032 | −2.96093 |
| — | — | 0.030372 | 2.20457 | |
| — | — | 0.034671 | −2.01378 | |
| Synaptic vesicle glycoprotein 2c | Sv2c | NM_029210 | 0.034726 | −2.22967 |
| — | — | 0.036855 | 2.21008 | |
| — | — | 0.037019 | 2.49757 | |
| — | — | 0.037103 | 2.077 | |
| Protocadherin β4 | Pcdhb4 | NM_053129 | 0.038903 | 2.04059 |
| Cytohesin 1-interacting protein | Cytip | NM_139200 | 0.039081 | 2.33386 |
| TOX high mobility group box family member 3 | Tox3 | NM_172913 | 0.040529 | −2.26008 |
| Thrombospondin, type I, domain-containing 4 | Thsd4 | NM_001040426 | 0.041443 | 2.06645 |
| Mucin 15 | Muc15 | NM_172979 | 0.043913 | 2.11666 |
| Claudin 8 | Cldn8 | NM_018778 | 0.045599 | 2.66327 |
| Protocadherin β2 | Pcdhb2 | NM_053127 | 0.048118 | 2.11683 |
| — | — | 0.048788 | 2.41597 | |
| Protocadherin β7 | Pcdhb7 | NM_053132 | 0.049552 | 2.15923 |
| Low density lipoprotein receptor class A domain-containing 3 | Ldlrad3 | NM_178886 | 0.050311 | −2.8352 |
a —, unidentified genes. SPARC, sereted protein, acidic, cystein-rich (osteonectin); LIM, lipophilic protein; TOX, thymocyte selection-associated high mobility group box.