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. 2012 Jun 4;287(30):25019–25029. doi: 10.1074/jbc.M112.372342

FIGURE 2.

FIGURE 2.

MINK1 is required for the completion of abscission. A, HeLa cells were transfected with control or MINK1 siRNAs; 48 h later, the cells were observed using time-lapse microscopy. Representative images of two types of cell divisions of MINK1 siRNA-transfected cells are shown. prolonged division indicates cells that completed cytokinesis with extended time period. failed division indicates cells that were unable to complete cytokinesis. The arrows point dividing cells. B, graph shows the ratio of cells that failed cytokinesis. Forty cells for each group of siRNA-transfected cells were evaluated, and three independent experiments were performed (the data are represented as the mean ± S.D.; **, p < 0.01). C, time period of each stage of mitosis was evaluated. The graph shows the average time period of 30 cells for each siRNA transfection (data represented as the mean ± S.D.; **, p < 0.01).