FIGURE 7.

Preservation of metabolic efficiency during streptozotocin-induced diabetes by cardiolipin synthase transgenic expression. High resolution respirometry using pyruvate (Pyr) with WT (A) or CLS transgenic mice (B) as well as palmitoyl-l-carnitine substrate (Palm-Carn) with WT (C) and CLS transgenic mice (D) stimulated respiration in sham-treated and STZ-induced diabetic mice. E, rate of ATP production driven by pyruvate or palmitoyl-l-carnitine. F, electron transport chain activities in diabetic and sham WT and CLS mice. Values represent the mean ± S.E. (error bars) (n = 5–8 different isolated mitochondria/group). *, p < 0.05; **, p < 0.01.