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. 2012 Jun 7;287(30):25073–25085. doi: 10.1074/jbc.M112.378737

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Chronic morphine increases glutamatergic input and presynaptic NMDAR activity in the spinal cord. A, original recording traces and cumulative plots show the effect of bath application of 50 μm AP5 on the frequency and amplitude of sEPSCs of a lamina II neuron from a vehicle-treated rat. B, original recordings and cumulative plots show the effect of 50 μm AP5 on sEPSCs of a lamina II neuron from a morphine-treated rat. C, summary data of the effect of 50 μm AP5 on the mean frequency and amplitude of sEPSCs in vehicle-treated (n = 13 neurons) and morphine-treated (n = 11 neurons) rats. D, group data of the effects of 50 μm AP5 on the mean frequency and amplitude of sEPSCs, recorded with 1 mm MK-801 included in the pipette solution, in morphine-treated rats (n = 11 neurons).*, p < 0.05 when compared with respective base-line controls. #, p < 0.05 when compared with base-line controls in vehicle-treated group.