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. 2012 Jun 7;287(30):25073–25085. doi: 10.1074/jbc.M112.378737

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Ablation of TRPV1-expressing primary afferents blocks the reduction in postsynaptic NMDAR activity in the spinal dorsal horn caused by chronic morphine. A, original traces show the effect of morphine treatment on monosynaptic NMDAR- and AMPAR-EPSCs of a lamina II neuron evoked by dorsal root stimulation in a RTX-treated and a vehicle-treated rat. B, group data show the effect of chronic morphine on the mean amplitude of evoked NMDAR- and AMPAR-EPSCs and the ratio of NMDAR-EPSCs to AMPAR-EPSCs in vehicle-treated (n = 14 neurons) and RTX-treated (n = 21 neurons) rats. Data from control rats not treated with morphine (n = 16 neurons) were included for comparison. C, original traces show the effect of chronic morphine on NMDAR currents elicited by puff application of 100 μm NMDA to a lamina II neuron in a vehicle-treated rat and an RTX-treated rat. D, group data show the effect of morphine on the mean amplitude of puff-induced NMDAR currents in vehicle-treated (n = 11 neurons) and RTX-treated (n = 16 neurons) rats. Note that data from control rats not treated with morphine (n = 14 neurons) were shown for comparison. *, p < 0.05 when compared with the base-line value in controls not treated with morphine.