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Model depicting the mechanisms of nickel-repressed E-cadherin in BEAS-2B cells. [1] nickel induces ROS generation and up-regulation of HIF-1α. [2] transcription factors, such as Snail and Slug, may be activated and inhibit expression of E-cadherin. Nickel represses E-cadherin by promoter hypermethylation via ROS generation.
