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Schematic presentation of editing pathways. Pre-transfer editing can occur through enhanced dissociation of noncognate aminoacyl-adenylate (pathway 2) or its enzymatic hydrolysis (pathways 1 and 3), which may be tRNA-independent (pathway 1) or tRNA-dependent (pathway 3). After transfer, mischarged tRNA can be deacylated through post-transfer editing (pathway 4).
