Figure 4.

Locomotor functions were not impaired by intrathecal treatments with TSP4 antibody or antisense oligodeoxynucleotides. a, b, Locomotor functions were analyzed with the Basso, Beattie, Bresnahan (BBB) locomotor rating scale in SNL rats before and after SNL surgery and treatments with antibodies (a) or oligodeoxynucleotides (b) as described. The post-treatment time points were 6 h after bolus antibody injections (a) or overnight after the last intrathecal injection of the 4 d antisense treatments (b); both were correlated with reversals of behavioral hypersensitivities shown in Figure 3b–d and 3e–g, respectively. Data presented are the mean ± SEM of ≥5 rats in each group. Tx, Treatment.