Genes regulated by HIF1α. HIF1α regulates a broad spectrum of genes under hypoxia, including genes involved in glucose transport (glucose transport 1 (GLUT1)), glycolysis (phosphoglycerate kinase 1 (PGK1)), angiogenesis (VEGF), tumor metastasis (lysyl oxidase (LOX), chemokine (C-X-C motif) receptor 4 (CXCR4), osteopontin (OPN)), and pH control (CA9). Recently, miR-210 was identified as a HIF1α target under hypoxia. MiR-210 suppresses the expression of a number of genes involved in a variety of cellular functions. By up-regulating miR-210 expression under hypoxia, HIF1α can indirectly inhibit the expression of a subset of genes so cells can adjust and adapt to the hypoxic environment.