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. 2009 Feb 4;29(5):1496–1502. doi: 10.1523/JNEUROSCI.5057-08.2009

Figure 2.

Figure 2.

Adolescent offspring of enriched juvenile ras-grf knock-out mice display normal LTP even if they are raised in conventional environment. a, LTP assays on hippocampal slices from 1-month-old ras-grf1/grf2 double knock-out mice exposed to either a conventional environment (black squares) or 2 weeks of enriched environment (red circles). n is number of slices and N is number of animals used. b, LTP assays of 1-month-old F1 offspring of either enriched (red circles) or unenriched (black squares) ras-grf knock-out mice. c, LTP assays on hippocampal slices from 1-month-old WT mice exposed to either a conventional environment (black squares) or 2 weeks of enriched environment (red circles). d, LTP assays of 1-month-old F1 offspring of either enriched (red circles) or unenriched (black squares) WT mice. Inset traces show a typical fEPSP from each group, gray traces are taken from 5 min before TBS, the colored traces are taken 50 min after TBS. Calibration: 1 mV, 10 ms. e, Immunoblot of brain slices demonstrating GRF1 and GRF 2 expression in WT but not F1 generation ras-grf1/2 double knock-out mice (mutant offspring) from enriched parents. The data represent the average and SEM from at least three independent experiments.