Table 2.
Descriptive characteristics of the medulloblastoma survivors and sibling participants
| Characteristic | Medulloblastoma Survivors (n = 109) | Siblings (n = 143) | P valuea |
|---|---|---|---|
| Gender | |||
| Male | 56 (51.4%) | 65 (45.5%) | NS |
| Female | 53 (48.6%) | 78 (54.5%) | |
| Age at time of questionnaire completion (yrs) | |||
| Mean (SD) | 30.9 (6.06) | 34.3 (9.00) | .0004 |
| Range | 18.6–43.7 | 18.9–54.6 | |
| Ethnicity | |||
| Caucasian | 98 (89.9%) | 131 (91.6%) | NS |
| Other | 11 (10.1%) | 5 (3.5%) | |
| Missing | 0 (0%) | 7 (4.9%) | |
| Highest education level | |||
| Less than 12th grade | 7 (6.4%) | 5 (3.5%) | .0002 |
| High school graduate | 32 (29.4%) | 15 (10.5%) | |
| Further education | 68 (62.4%) | 123 (86.0%) | |
| Unknown | 2 (1.8%) | 0 (0%) | |
| Age at diagnosis (yrs) | |||
| Mean (SD) | 8.0 (0.41) | N/A | |
| Range | 0.6–18.3 | ||
| Time since diagnosis at time of questionnaire completion (yrs) | |||
| Mean (SD) | 22.8 (4.22) | N/A | |
| Range | 16.5–32.5 | ||
| Received Chemotherapy | |||
| Yes | 53 (48.6%) | N/A | |
| No | 51 (46.8%) | ||
| Unknown | 5 (4.6%) | ||
| Radiation Doses (Gy) Mean (SD) | |||
| Posterior Fossa (Segment 1) | 50.4 (6.01) | N/A | |
| Temporal (Segment 2) | 43.1 (9.53) | ||
| Frontal (Segment 3) | 36.9 (7.64) | ||
| Parietal/Occipital (Segment 4) | 40.1 (8.21) | ||
| SOD2 (47T > C) | |||
| TT | 21 (19.3%) | 34 (23.8%) | NS |
| CT | 50 (45.9%) | 78 (54.5%) | |
| CC | 37 (33.9%) | 31 (21.7%) | |
| Missing | 1 (0.9%) | 0 | |
| GPX1 (599C > T) | |||
| CC | 50 (45.9%) | 71 (49.7%) | NS |
| CT | 47 (43.1%) | 58 (40.5%) | |
| TT | 8 (7.3%) | 8 (5.6%) | |
| Missing | 4 (3.7%) | 6 (4.2%) | |
| GSTP1(1404A > G and 2294C > T) | |||
| AA | 45 (41.3%) | 60 (42.0%) | NS |
| Non AA | 64 (58.7%) | 83 (58%) | |
| GSTM1 (Gene deletion) | |||
| Null | 51 (46.8%) | 71 (49.6%) | NS |
| Non-null | 57 (52.3%) | 72 (50.4%) | |
| Missing | 1 (0.9%) | 0 | |
| GSTT1 (Gene deletion) | |||
| Null | 19 (17.4%) | 21 (14.7%) | NS |
| Non-null | 89 (81.7%) | 122 (85.3%) | |
| Missing | 1 (0.9%) | 0 |
aP-value was based on those participants without missing data.