Fig. 3.

Tropism of MPIO-labeled SCs toward areas of high permeability at the edge of and, inside U87vIII tumors following contralateral injections. (A) Axial T2*-w MRI slices of 1 U87vIII tumor-bearing mouse 7 days after contralateral injection of MPIO-labeled hMSCs and (B) corresponding CE-MR images, confirming the colocalization of MPIO-induced areas of hyposignal with the edges of the post-Gd enhancing tumors. The MPIO-labeled SC injection sites are shown as empty circles, the tumor injection sites as filled circles. The dotted lines show the localization of the displayed imaging slices. MPIO-labeled SCs localized at the edges of the tumors in areas of high permeability (black arrows) and inside the tumor masses (white arrows).