Table 3.
Mortality rate and multivariable Cox proportional hazards regression model measured hazard ratio (HR) and 95% confidence interval (CI) of mortality by demographic status, co-morbidity and stage of lung cancer
| Variables | N | Death | Person-days | Mortality rate | Rate ratio (95%CI) | HRs* (95% CI) | p-value | ||
|---|---|---|---|---|---|---|---|---|---|
|
Overall |
1111 |
738 |
857762 |
0.86 |
|
|
|
|
|
|
Gender |
|
|
|
|
|
|
|
|
|
| Male |
822 |
565 |
615638 |
0.92 |
1.28 |
(1.08-1.52) |
1.44 |
(1.20-1.72) |
<0.001 |
| Female |
289 |
173 |
242124 |
0.71 |
1.00 |
|
1.00 |
|
|
|
Age, years |
|
|
|
|
|
|
|
|
|
| ≤ 50 |
94 |
68 |
54514 |
1.25 |
1.47 |
(1.14-1.90) |
1.29 |
(0.99-1.70) |
0.064 |
| 51 - 60 |
155 |
98 |
114428 |
0.86 |
1.01 |
(0.81-1.26) |
0.89 |
(0.71-1.12) |
0.328 |
| 61 - 70 |
290 |
183 |
229726 |
0.80 |
0.94 |
(0.79-1.12) |
1.00 |
(0.83-1.20) |
0.994 |
| ≥ 71 |
572 |
389 |
459094 |
0.85 |
1.00 |
|
1.00 |
|
|
|
Comorbidity |
|
|
|
|
|
|
|
|
|
| Other Cancer |
|
|
|
|
|
|
|
|
|
| No |
1031 |
690 |
787641 |
0.88 |
1.00 |
|
1.00 |
|
|
| Yes |
64 |
38 |
57496 |
0.66 |
0.75 |
(0.54-1.05) |
0.77 |
(0.55-1.07) |
0.124 |
| Tuberculosis |
|
|
|
|
|
|
|
|
|
| No |
989 |
649 |
783186 |
0.83 |
1.00 |
|
1.00 |
|
|
| Yes |
106 |
79 |
61951 |
1.28 |
1.54 |
(1.22-1.94) |
1.30 |
(1.03-1.65) |
0.030 |
| COPD |
|
|
|
|
|
|
|
|
|
| No |
1040 |
696 |
795978 |
0.87 |
1.00 |
|
1.00 |
|
|
| Yes |
55 |
32 |
49159 |
0.65 |
0.74 |
(0.52-1.06) |
0.97 |
(0.67-1.38) |
0.848 |
| Diabetes |
|
|
|
|
|
|
|
|
|
| No |
967 |
633 |
768281 |
0.82 |
1.00 |
|
1.00 |
|
|
| Yes |
128 |
95 |
76856 |
1.24 |
1.50 |
(1.21-1.86) |
1.44 |
(1.15-1.80) |
0.002 |
| Hypertension |
|
|
|
|
|
|
|
|
|
| No |
808 |
534 |
636661 |
0.84 |
1.00 |
|
1.00 |
|
|
| Yes |
287 |
194 |
208476 |
0.93 |
1.11 |
(0.94-1.31) |
1.07 |
(0.90-1.27) |
0.453 |
|
Stage |
|
|
|
|
|
|
|
|
|
| I |
216 |
73 |
264485 |
0.28 |
1.00 |
|
1.00 |
|
|
| II |
106 |
60 |
110785 |
0.54 |
1.96 |
(1.39-2.76) |
1.85 |
(1.30-2.61) |
0.001 |
| III |
406 |
289 |
295328 |
0.98 |
3.55 |
(2.74-4.58) |
3.35 |
(2.57-4.35) |
<0.001 |
| IV |
383 |
316 |
187164 |
1.69 |
6.12 |
(4.74-7.89) |
5.63 |
(4.32-7.33) |
<0.001 |
| p for trend | <0.001 | ||||||||
COPD: chronic obstructive pulmonary disease.
* Adjusted Hazard Ratios, obtained with statistical adjustment for all the variables listed in this table.