Figure 2.
Antibody response to VLP and adenoviral vector immunization in immunodeficient (A-C) and immunocompetent (A,B) mice. Mice were immunized with SIV VLPs at the indicated dose of gp140 ectodomain (ng) and route on days 0, 35 and 45. Subcutaneous adenoviral vector immunizations (Ad-SIV) with 1 × 109 particles were performed on day 0 and 35. Serum antibody levels of the indicated isotypes (A-C) to Env and Gag were determined before immunization (0) and on day 49.