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. 2012 Jul 30;7(7):e41932. doi: 10.1371/journal.pone.0041932

Figure 6. A proposed model of DV capsid protein induces HMGB1 release from monocytes.

Figure 6

DV enters the monocytes and uncoat. The capsid protein enters the nucleus and triggers the acetylation of HMGB1 by PCAF complex. HMGB1 then translocates from the nucleus to cytoplasm, a process that can be inhibited by EP. HMGB1 gets released from the monocytes and binds to RAGE receptors on endothelial cells, triggering a signalling pathway which leads to the lost of vascular integrity. The increased in vascular leakage can be repressed by HMGB1-neutraling antibody or anti-RAGE antibody.