Figure 4. Dose and LET dependent kinetics of Rad52.
10–20 min after irradiation with 43 MeV carbon ions (5.6 Gy, one ion per point) foci become visible. When applying the similar dose by 117 20 MeV protons per point first very weakly developed foci become visible not before three hours have elapsed (upper right nucleus). Increasing the number of protons per point accelerates the kinetics; with 512 protons per point (i.e. 24 Gy) already ten minutes after irradiation foci can be seen, so that kinetics is similar to that of 5.6 Gy carbon irradiation. Scale bars 20 µm.