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. 2012 Jul 30;7(7):e41943. doi: 10.1371/journal.pone.0041943

Figure 5. Comparison of the kinetics of Mdc1 and 53BP1 after carbon and proton irradiation.

Figure 5

The shaded areas show the 1 σ error bands for the fit functions. A strong LET dependency of Mdc1 is visible. For 53BP1 only the time lag after which foci formation starts shifts from high LET to low LET. The models are based on data obtained after irradiation of U2OS pEGFP-Mdc1 clone F1 with 5.2 Gy carbon ions or 4.8 Gy protons, and Hela pMC16-53BP1-GFP clone #5 with 7.6 Gy carbon ions or 6.9 Gy protons, respectively.