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. 2012 Aug 1;23(15):2845–2855. doi: 10.1091/mbc.E12-02-0097

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© 2012 Senga et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — Cldn3 and Rab25 have additive effect on increasing barrier function and the lumen size. (A) HPPL-Cldn3+Rab25 shows stronger barrier function than HPPL-Cldn3 or HPPL-Rab25. Paracellular efflux of 4-kDa FITC-dextran is further decreased by coexpression of Cldn3 and Rab25 in HPPL as compared with expression of either of them. (B) HPPL-Cldn3+Rab25 and HPPL-Grhl2 show similar barrier function. (C) HPPL-Cldn3+Rab25 form significantly larger cysts than HPPL-Cldn3 or HPPL-Rab25. The size of lumen is further increased by coexpression of Cldn3 and Rab25 in HPPL as compared with expression of either of them. A dot plot for a representative culture is shown. The diameter of the lumen was measured for >50 cysts per culture. Experiment was repeated for three times independently. (D) HPPL-Grhl2 forms significantly larger cysts than HPPL-Cldn3+Rab25.

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