Table 1. Effect of ShRNA-mediated Sprn knockdown on embryo resorption at E11.5.
| Lentivirus | FoxL2 | FoxL2 | FoxL2 | Shadoo (LS2) | Shadoo (LS2) | Shadoo (LS2) | None |
| Genetic Background | FVB/N | FVB/N Prnp 0/0 | P10 | FVB/N | FVB/N Prnp 0/0 | P10 | P10 |
| Implanted | 56 | 41 | 79 | 101 | 128 | 105 | 28 |
| Resorbed | 28 | 16 | 39 | 49 | 96 | 36 | 5 |
| % Resorbed | 50 | 39 | 49 | 48.5 | 75* | 34.3 | 17.8 |
*
p<0.05 (x2 test) when compared to any of the FoxL2 results and to LS2 on P10 and FVB/N genetic backgrounds.
These data are a compilation of at least 2 independent experiments. No statistically significant variability was observed between the analyzed litters (3 for P10, more than 4 for the other lentiviral infections).