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. 2012 Jul 30;7(7):e42132. doi: 10.1371/journal.pone.0042132

Figure 8. Model of the role of PG in prostate cancer adhesion and motility.

Figure 8

Loss of PG results in a double negative hit on cell-cell junctions, while orchestrating alterations in extracellular matrix that promote motility. PG levels correspond directly to the strength of cell-cell adhesion in PCa cells. Down-regulation of PG leads to loss of cell-cell adhesion strength. Concomitantly, loss of PG causes up-regulation of VN and activation of Src. Together, these cell-cell and cell-ECM dependent effects of PG down-regulation lead to an increase in PCa cell motility.