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. 2012 Jul 30;7(7):e39485. doi: 10.1371/journal.pone.0039485

Figure 12. Ligand 7 protects against Aβ-induced LTP impairment.

Figure 12

(A) The oligomeric Aβ(1–42) sample applied at 720 nM hinders synaptic potentiation. (B) Compound 7 applied at 950 nM prevents the LTP impairment caused by Aβ(1–42) oligomers. The control substance 11 has no effect against Aβ(1–42) oligomers. (C) Neither 7 nor 11 alone exerted any effect on LTP in the absence of Aβ oligomers. (D) The summarized results observed 180 min after LTP (**P<0.01, ***P<0.001 versus control). Statistical analysis was carried out by using two-tailed Student's t-test, n = 6 or 7 slices per group. Data are presented as means ±SEM. (E) Divalent 8 applied at 950 nM did not exhibit statistically significant effect against Aβ(1–42) oligomers. Arrows indicate LTP induction, EPSP stands for excitatory postsynaptic potential.