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. 2012 Jul 30;7(7):e41076. doi: 10.1371/journal.pone.0041076

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© 2012 Kulpa et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Hearts were perfused with an inhibitor of p38 MAPK (SB203580, 1 µM) 5 min prior to and during perfusion with 100 nM PPT. A. 1 min PPT. B. 2.5 min PPT. C. 5 min PPT. Inhibition of p38 MAPK blocked the effects of PPT on actomyosin MgATPase activity at all time points. D. Treatment with SB203580 had no effect on myofilament activation at all timepoints. N = 5 for all groups.