Table 2. Follow up of glucose, amino acid and betaine signals.

	HNF1A-MODY	GCK-MODY	T2D	p	C statistic HNF1A vs T2D
Urine Glucose	n = 27	n = 17	n = 158
Urinary glucose/Cr ratio (mmol/mmol)	0.67(1.84)	0.039(0.024)	0.13(1.88)	*0.01	0.58
Plasma glucose/Urinary glucose ratio (mmol/mmol)	0.73(5.87)	12.41(9.47)	6.92(19.14)	*0.04	0.63
Plasma glucose/(Urinary glucose/ creatinine ratio) mmol/ (mmol/mmol)	13.1 (138.3)	178. 9 (100.3)	72.0 (174.7)	*0.01	0.55
Amino Acids	n = 22		n = 22-
Valine/Cr ratio (µmol/mmol)	0.35 (0.62)		0.67 (0.92)	0.08
Alanine/Cr ratio (µmol/mmol)	2.00 (3.80)		4.79 (4.61)	0.18
One-Carbon compounds	n = 39		N = 80
Glycine/Cr ratio (µmol/mmol)	93.6 (73.6)		88.1 (68.0)	0.87
Urinary betaine/Cr ratio (µmol/mmol)	19.5 (28.2)		34.9 (52.9)	<0.001	0.70
Sarcosine/Cr ratio (µmol/mmol)	0.21 (0.25)		0.27 (0.24)	0.03	0.63
Choline/Cr ratio (µmol/mmol)	2.75 (2.59)		4.00 (3.43)	0.003	0.67

Data are median (IQR). P values compare HNF1A and T2D using Mann Whitney U test except for * where comparisons between all 3 groups are calculated by Kruskal-Wallis test.