Table 2. Percentage Symptom Reduction with Active Treatments and Controls among Depression Trials with an Un-blinded Rater.

	Combination	Antidepressants	Psychotherapy	Alternative Therapy	Active Intervention Control	Treatment as Usual	Waiting List Control
Combination (k = 8)	66%*
Antidepressants (k = 17)	p = 0.044a	54%*
Psychotherapy (k = 78)	p = 0.016a	NSb	53%*
Alternative Therapy (k = 6)	p = 0.049a	NSb	NSc	50%*
Active Intervention Control (k = 22)	p = 0.001a	p = 0.057b	p = 0.055c	NS	47%*
Treatment as Usual (k = 6)	p<0.001a	p<0.001b	p<0.001c	p<0.001d	p<0.001e	24%*
Waiting-list Control (k = 20)	p<0.001a	p<0.001b	p<0.001c	p<0.001d	p<0.001e	p = 0.016f	12%*

^*Percentage symptom reduction values are weighted by number of patients per treatment arm for each active intervention and control for 59 un-blinded depression treatment trials with 157 treatment arms enrolling 4,083 patients.

Bolded text represents four active depression treatments. Italic text represents three treatment controls.

k = number of treatment arms for each therapy type.

Probability values show the statistical significance of comparisons between the treatment or control on the vertical access versus treatment or control on the horizontal access.

NS = Not Significant.

^aCombination antidepressant therapy versus other treatments and controls.

^bAntidepressant therapy versus other treatments and controls.

^cPsychotherapy versus other treatments and controls.

^dAlternative therapy versus treatment controls.

^eActive intervention control versus treatment as usual and waiting-list controls.

^fTreatment as usual versus waiting list control.

Analysis of Variance F Value (150 df) = 28.9, p<0.001, statistical significance determined with Tukey’s Post Hoc Test of Least Significant Difference.