Table 3. Percentage Symptom Reduction with Active Treatments and Controls among Depression Trials with a Blinded Rater.

		Combination		Antidepressants		Psychotherapy		Alternative Therapy		Active Intervention Control		Placebo Control		Treatment as Usual		Waiting List Control
Combination (k = 24)	52%*
Antidepressants (k = 24)	p = 0.027a		46%*
Psychotherapy (k = 50)	p = 0.022a		NSb		47%*
Alternative Therapy (k = 12)	NSa		NSb		NSc		47%*
Active Intervention Control (k = 26)	p = 0.008a		NSb		NSc		NSd		42%*		NSe
Placebo Control (k = 16)	p<0.001a		p = 0.030b		p = 0.019c		p = .066d		NSe		38%*
Treatment as Usual (k = 6)	p<0.001a		p = 0.017b		p = 0.012c		p = 0.035d		NSe		NSf		36%*
Waiting-list Control (k = 14)	P<0.001a		p<0.001b		p<0.001c		p<0.001d		p<0.001f		p<0.001e		p<0.001g		13%*

^*Percentage symptom reduction values are weighted by number of patients per treatment arm for each active intervention and control for 56 blinded depression treatment trials with 171 treatment arms enrolling 6,227 patients.

Bolded text represents four active depression treatments. Italic text represents the four treatment controls.

k = number of treatment arms for each therapy type.

Probability values show the statistical significance of comparisons between the treatment or control on the vertical access versus treatment or control on the horizontal access.

NS = Not Significant.

^aCombination antidepressant therapy versus other treatments and controls.

^bAntidepressant therapy versus other treatments and controls.

^cPsychotherapy versus other treatments and controls.

^dAlternative therapy versus treatment controls.

^eActive intervention control versus treatment as usual and waiting-list controls.

^fPlacebo versus other treatment controls.

^gTreatment as usual versus waiting list control.

Analysis of Variance F Value (163 df) = 11.99, p<0.001, statistical significance determined with Tukey’s Post Hoc Test of Least Significant Difference.