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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Am J Kidney Dis. 2012 Apr 25;60(3):390–401. doi: 10.1053/j.ajkd.2012.03.009

Table 1.

Clinical and demographic features of participants by randomization arm

High Hb [13.5 g/dL] target
(n=711)		 Low Hb [11.3 g/dL] target
(n=710)		 P-Value
Age (y) 66.0 ± 14.3 66.3 ± 13.5 0.7
Female gender 401 (56.4%) 382 (53.8%) 0.3
Race
    White
    Black
    American Indian/Alaskan Native
    Asian or Pacific Islander
    Other
443 (62.5)
201 (28.3)
1 (0.1)
24 (3.4)
40 (5.6)
434 (61.1)
208 (29.3)
3 (0.4)
23 (3.2)
42 (5.9)		 0.9
Hispanic Ethnicity 89/708 (12.6%) 95/709 (13.4%) 0.6
Current Smoker (vs. Never/Past Smoker) 40/708 (5.6%) 50/710 (7.0%) 0.3
Comorbid Conditions
    Atrial fibrillation/flutter
    Diabetes mellitus
    Coronary artery disease 1
    Cerebrovascular disease 2
    Heart failure 3
    Hypertension
    History of solid organ malignancy
    Thromboembolic disease 4
    Peripheral vascular disease 5
    Cardiovascular disease composite 6
63/668 (9.4)
435/707 (61.5)
232/669 (34.7)
88/670 (13.1)
191/668 (28.6)
641/669 (95.8)
90/664 (13.6)
37/669 (5.5)
115/668 (17.2)
319/669 (47.7)
58/667 (8.7)
452/709 (63.8)
214/668 (32.0)
98/665 (14.7)
181/667 (27.1)
623/669 (93.1)
93/665 (14.0)
48/665 (7.2)
115/665 (17.3)
319/665 (47.9)
0.6
0.4
0.3
0.4
0.6
0.03
0.8
0.2
0.9
0.9
Baseline Laboratory Values
    eGFR (mL/min/1.73m^2)
    Albumin (mg/dl)
    UPCR (mg/mg)
    Cholesterol (mg/dl)
    Ferritin (mg/dl)
    Transferrin saturation (%)
    Hb (g/dl)
25.2. [19.6–32.7]
3.8 [3.4–4.0]
0.6 [0.2–2.2]
178 [149–212]
119 [59.8–223]
23.1 [17.6–30.2]
10.2 [9.6–10.7]
25.4 [19.8–33.0]
3.8 [3.5–4.1]
0.6 [0.2–1.8]
175 [151–211]
123 [62.9–236]
23.2 [18.1–30.2]
10.2 [9.6–10.7]
0.6
0.2
0.2
0.8
0.2
0.8
0.5
Inflammation or malnutrition* 282/709 (39.8) 258/707 (36.5) 0.2

Values for continuous variables given as mean ± SD or median [25th–75th percentile]; values for categorical variables given as number (percentage) or n/N (%).

eGFR, estimated glomerular filtration rate; UPCR, urine total protein–creatinine ratio; Hb, hemoglobin.

Conversion factor for cholesterol in mg/dL to mmol/L, ×0.02586.

1

Coronary artery disease = prior myocardial infarction, angina, coronary artery bypass graft or percutaneous intervention

2

Cerebrovascular disease = prior cerebrovascular accident or transient ischemic attack

3

Heart failure = prior congestive heart failure, cardiomyopathy, left or right ventricular dysfunction

4

Prior thromboembolic disease = prior pulmonary embolism, arterial thrombosis, deep venous thromboembolism, or hypercoagulable state

5

Peripheral vascular disease = prior PVD or lower extremity amputation

6

Cardiovascular disease composite = CAD, CVA/TIA, or PVD

*

albumin <3.6 mg/dL or ferritin >600 mg/dL