Table 1.
Baseline characteristics relating to frequency of NASRA
| Characteristic: | Number of annualized NASRA | P value | ||
|---|---|---|---|---|
| 0 NASRA (79 subjects) |
1–12 NASRA (136 subjects) |
≥13 NASRA (69 subjects) |
||
| Male gender, n (%) | 50 (63.3) | 88 (64.7) | 36 (52.5) | NS |
| BMI | 19.5 ± 4.0 | 20.1 ± 4.8 | 20.3 ± 5.8 | NS |
| Non-Caucasian race*, n (%) | 13 (16.5) | 23 (16.9) | 22 (31.2) | 0.03 |
| Age at randomization (years) | 10.0 ± 2.2 | 9.8 ± 2.3 | 9.7 ± 2.0 | NS |
| Age at onset of asthma (years) | 3.6 ± 2.8 | 3.1 ± 2.7 | 3.0 ± 2.7 | NS |
| Number of NASRA/subject during the 14 day run-in period | 0.10 ± 0.3 | 0.58 ± 1.1 | 1.3 ± 1.5 | <0.0001 |
| Number of asthma-free days/subject during the 14-day run-in period | 4.7 ± 3.7 | 3.5 ± 3.0 | 3.4 ± 3.0 | 0.008 |
| AM PEF during run-in period (L/min) | 252.0 ± 72.0 | 244.8 ± 71.8 | 248.6 ± 58.4 | NS |
| PM PEF during run-in period (L/min) | 256.8 ± 69.8 | 251.9 ± 74.1 | 254.7 ± 59.1 | NS |
| PEF variability during run-in period (%) | 9.3 ± 4.6 | 10.2 ± 5.8 | 9.8 ± 4.7 | NS |
| Pre-BD FEV1 (% predicted) | 98.8 ± 11.2 | 96.3 ± 12.8 | 98.3 ± 12.4 | NS |
| Pre-BD FEV1/FVC (%) | 80.9 ± 7.5 | 78.8 ± 7.7 | 81.3 ± 7.8 | NS |
| Maximum BD response (%) | 9.9 ± 7.3 | 10.9 ± 7.5 | 11.1 ± 8.3 | NS |
| Peripheral Blood Eosinophils (%) | 5.4 ± 3.6 | 6.1 ± 4.6 | 6.4 ± 3.8 | NS |
| PC20 (mg/mL), median (Quartile 1, Quartile 3) | 1.1 (0.4, 2.6) | 0.8 (0.3, 2.5) | 0.8 (2, 2.9) | NS |
| FeNO (ppb), median (Quartile 1, Quartile 3) | 24.8 (9.7, 50.5) | 22.7 (12.8, 51.3) | 31.9 (12.6, 58.0) | NS |
| IgE (IU/mL), median (Quartile 1, Quartile 3) | 129.0 (40.9, 363.0) | 164 (61.7, 363.0) | 176.0 (69.0, 415.0) | NS |
| At least 1 positive skin test, n (%) | 58 (73.4) | 109 (80.2) | 55 (79.7) | NS |
| Medication use in prior year: | ||||
| Inhaled or nebulized corticosteroids, n (%) | 44 (55.7) | 80 (58.5) | 36 (52.2) | NS |
| Fluticasone/salmeterol combination, n (%) | 10 (12.7) | 15 (11.4) | 10 (13.7) | NS |
| Montelukast, n (%) | 28 (35.4) | 52 (38.2) | 15 (21.7) | NS |
Data represent mean ± SD except as noted.
*
Non-Caucasian race was 73% Black, 17% American Indian, 3% Asian and 7% Pacific Islander.