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. Author manuscript; available in PMC: 2012 Jul 31.
Published in final edited form as: J Comp Neurol. 2001 May 7;433(3):415–425. doi: 10.1002/cne.1149

Fig. 4.

Fig. 4

Cholinergic neurons are present in the cerebral cortex, basal forebrain, and striatum of the NPC+/+ and NPC−/− mouse. Cholinergic neurons, immunostained with an antibody against ChAT appear black and are illustrated in the NPC+/+ mouse (A,C,E) and NPC−/− mouse (B,D,F). The distribution of cholinergic neurons is similar in the two mouse types. A,B: Cholinergic nerve terminals in the cerebral cortex are found in both mouse types, but they are often swollen in size in the NPC−/− animals (small arrows). There are also small cholinergic somata in the cortox of both animal types (curved arrows). C,D: Large cholinergic somata are present in the basal fore-brain in both animal types (curved arrows point to one of several such cells). E,F:Largo cholinergic somata are present in the striatum in both animal types (curved arrows point to one of several such cells). The size of the striatal cholinergic neurons is 9% larger in the NPC−/− animal vs. NPC+/+ animal (see Table 2). Scale bar = 20 µm.