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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Surgery. 2012 Aug;152(2):286–293. doi: 10.1016/j.surg.2012.05.009

Figure 1. Tumorigenesis Protocol.

Figure 1

Inducible, enterocyte-specific p38 deletion was induced by intraperitoneal (IP) tamoxifen (TAM) injection (0.5mg/day) on days 1–3. Azoxymethane (AOM, 10mg/kg) was injected IP on day 8. On day 13 2.5% dextran sodium sulfate (DSS) was administered to mice in their drinking water for seven days. On day 20 mice were given water for 14 days to recover. Mice underwent three cycles of DSS treatment followed by water. Control mice were given water for the entire protocol instead of DSS. Animals were sacrificed on day 77.