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. 2012 Jul 2;122(8):2837–2846. doi: 10.1172/JCI59373

Figure 3. Increased cyclocreatine content in brain after cyclocreatine treatment.

Figure 3

(A) Cyclocreatine (cCr) and (B) creatine (Cr) content in brains of Slc6a8–/y mice (n = 7 [cyclocreatine]; 5 [creatine and placebo]) and Slc6a8fl/y littermate controls (n = 5 per group) after 9 weeks of treatment, measured by biochemical assays. P, placebo. Data are mean ± SEM. ***P ≤ 0.001 vs. Slc6a8fl/y; ###P ≤ 0.001 as indicated by brackets.