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. 2012 Jul 2;122(8):2837–2846. doi: 10.1172/JCI59373

Figure 4. Phosphorylated metabolites in the brain, measured by 31P-MRS.

Figure 4

An indirect measure of the phosphate metabolites was determined by taking the peak height of the metabolite of interest and dividing by the sum of all the other phosphate metabolites. (A) Baseline measurements (n = 3 per group) of inorganic phosphate (Pi), phosphocreatine (PCr), and β-adenosine triphosphate (β-ATP). (B) Ratio of phosphocreatine plus phosphorylated cyclocreatine (PcCr) to total phosphorylated metabolites after 9 weeks of treatment (n = 3 per group). Data are mean ± SEM. *P ≤ 0.05, **P ≤ 0.01 vs. Slc6a8fl/y.